Your hardware is too new. The legacy kernel lacks drivers for your motherboard chipset. Abandon the ISO and use the from Part 4.

andreipop June 27, 2021, 7:50pm 14. It is actualy 16 years old. And seems like the isue was never solved. Semms like nobody cares. MikroTik community forum

This guide covers causes, diagnostics, and step‑by‑step fixes for the “Fatal error: No CD-ROM found” message encountered when installing MikroTik RouterOS (typically from a CD, USB, or PXE). It assumes you’re installing RouterOS on x86/amd64 hardware or a virtual machine and that the installer fails early with that error.