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In cinema and television, chloroform is often used as a tool for nefarious characters to incapacitate their victims. This can be seen in movies like (1960), where Norman Bates uses chloroform to sedate Marion Crane, and True Detective (TV series, 2014), where a character uses chloroform to knock out a victim. These portrayals perpetuate the idea that chloroform is a quick and effective way to render someone unconscious.

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Despite the scientific inaccuracies, the "chloroform rag" remains a staple of entertainment content because it is . It conveys a clear message to the audience: the stakes have changed, and this character is now powerless. In cinema and television, chloroform is often used