Edmund McMillen has repeatedly stated that Android fragmentation, screen size variety, and control issues make a proper port difficult. The only way to play Isaac on Android:
Many use Switch emulators like Skyline or Yuzu (on compatible hardware) to run the console version of Repentance . The Binding Of Isaac Mobile Port
Bringing the Basement to Your Pocket: The Binding of Isaac Mobile screen size variety
Isaac adjusted his glasses. He felt a bead of sweat trace the line of his jaw. "It’s the tears, sir." The Binding Of Isaac Mobile Port