"Hichki" stars Nandita Das in the lead role of Anjali, a young woman who suffers from Tourette's syndrome, a neurodevelopmental disorder that causes repetitive movements and vocalizations, known as tics. Despite her condition, Anjali is determined to become a teacher and make a difference in the lives of her students.
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The film tells the story of Naina Agarwal (played by Nayanthara), a talented young singer who suffers from a rare neurological disorder called Tourette's syndrome. Due to her condition, Naina experiences uncontrollable hiccups, which make it challenging for her to lead a normal life. Despite her struggles, Naina dreams of becoming a successful singer and teacher. She gets an opportunity to work as a teacher at a prestigious school, where she faces initial difficulties but eventually wins over her students and colleagues with her dedication and passion.